Trial Profile

A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 19 Sep 2026

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At a glance

Drugs Adagrasib (Primary) ; Cetuximab (Primary) ; Aflibercept; Bevacizumab; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin; Ramucirumab
Indications Carcinoma; Colorectal cancer
Focus Registrational; Therapeutic Use
Acronyms KRYSTAL-10; KRYSTAL10
Sponsors Mirati Therapeutics

17 Jul 2026 This trial has been completed in Greece, Portugal and Finland, As per CTIS record
27 Apr 2026 Planned End Date changed from 30 Jan 2026 to 31 Jul 2026.
09 Jan 2025 Planned End Date changed from 28 Feb 2026 to 30 Jan 2026.

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