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A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

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Trial Profile

A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 29 Jul 2024

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At a glance

  • Drugs Adagrasib (Primary) ; Cetuximab (Primary) ; Aflibercept; Bevacizumab; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin; Ramucirumab
  • Indications Carcinoma; Colorectal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KRYSTAL-10; KRYSTAL10
  • Sponsors Mirati Therapeutics

    • Most Recent Events

    • 12 Mar 2024 Planned End Date changed from 30 Dec 2024 to 28 Feb 2026.
    • 12 Mar 2024 Planned primary completion date changed from 30 Apr 2024 to 28 Feb 2025.
    • 27 Feb 2024 According to a Zai Lab media release, the Zai Lab is participating in this global confirmatory trial in Greater China.

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