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A Multicenter, Open-Label, Phase Ib/II Study of ADG106 in Combination With PD-1 Antibody in Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma

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Trial Profile

A Multicenter, Open-Label, Phase Ib/II Study of ADG106 in Combination With PD-1 Antibody in Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 26 Apr 2023

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At a glance

  • Drugs ADG 106 (Primary) ; Toripalimab (Primary)
  • Indications Non-Hodgkin's lymphoma; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Adagene

    • Most Recent Events

    • 20 Apr 2023 Status changed from recruiting to discontinued as the safety of ADG106 combined with triprilimab has been fully understood. The overall clinical benefit of enrolled subjects was limited and further development of ADG106 was reconsidered.
    • 30 Aug 2022 According to an Adagene media release, Given prioritization of its two anti-CTLA-4 clinical programs and potential of its next generation anti-CD137 therapy, ADG206, Adagene is winding down this trial.
    • 30 Aug 2022 According to an Adagene media release, currently four patients remain on therapy in the trial.

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