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REVEAL Adult Study: An Open-label, Randomized, Doseescalation- and Dose-expansion Study of the Safety and Preliminary Efficacy of a Single Intrathecal Administration of TSHA-102, an AAV9-Delivered Gene Therapy, in the Treatment of Adult Females With Rett Syndrome

Trial Profile

REVEAL Adult Study: An Open-label, Randomized, Doseescalation- and Dose-expansion Study of the Safety and Preliminary Efficacy of a Single Intrathecal Administration of TSHA-102, an AAV9-Delivered Gene Therapy, in the Treatment of Adult Females With Rett Syndrome

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Jun 2025

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At a glance

  • Drugs TSHA 102 (Primary)
  • Indications Rett syndrome
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms REVEAL; REVEAL Adult Study
  • Sponsors Taysha Gene Therapies

Most Recent Events

  • 10 Jun 2025 Planned primary completion date changed from 31 Jan 2025 to 2 Nov 2028.
  • 28 May 2025 According to a Taysha Gene Therapies media release, company will host three oral presentations related to TSHA-102 at the upcoming 2025 IRSF Rett Syndrome Scientific Meeting taking place in Boston from June 9-11, 2025.
  • 28 May 2025 Results presented in the Taysha Gene Therapies media release.

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