Trial Profile

Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study of TransCon TLR7/8 Agonist Alone or in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Status: Discontinued

Phase of Trial: Phase I/II

Latest Information Update: 16 Apr 2026

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At a glance

Drugs Pembrolizumab (Primary) ; TransCon TLR7/8 Agonist (Primary)
Indications Anal cancer; Cervical cancer; Head and neck cancer; Malignant melanoma; Penile cancer; Solid tumours; Squamous cell cancer; Vulvovaginal cancer
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms transcendIT-101
Sponsors Ascendis Pharma

16 Apr 2026 Last checked against Clinical Trials Information System
20 Jan 2026 Status changed from active, no longer recruiting to discontinued.
05 Jun 2025 Planned primary completion date changed from 1 May 2025 to 1 Jan 2026.

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