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A Phase 1/2, Open-Label, Multi-Center, Dose Escalation and Expansion Study Evaluating the Safety, Tolerability and Clinical Activity of DECOY20 as Monotherapy and in Combination With Tislelizumab in Patients With Advanced Solid Tumors

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Trial Profile

A Phase 1/2, Open-Label, Multi-Center, Dose Escalation and Expansion Study Evaluating the Safety, Tolerability and Clinical Activity of DECOY20 as Monotherapy and in Combination With Tislelizumab in Patients With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 10 Jun 2025

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At a glance

  • Drugs Decoy 20 (Primary) ; Tislelizumab (Primary)
  • Indications Carcinoma; Head and neck cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man
  • Sponsors Indaptus Therapeutics

Most Recent Events

  • 02 Jun 2025 According to an Indaptus Therapeutics media release, the first patient has been dosed in the expansion arm of its Phase 1b/2 clinical trial evaluating Decoy20 in combination with BeOne's (formerly known as Beigene) PD-1 checkpoint inhibitor, tislelizumab.
  • 14 May 2025 According to an Indaptus Therapeutics media release, to date, 32 patients have been enrolled, in the weekly dosing among the two Decoy20 dose levels and to conclude enrollment for this arm and move to the combination treatment of Decoy20 with Tislelizumab.
  • 20 Mar 2025 Pharmacodynamics findings from this study presented in an Indaptus Therapeutics media release.

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