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A PHASE 1, OPEN-LABEL, MULTI-CENTER, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY EVIDENCE OF ANTI-TUMOR ACTIVITY OF PF-07284892 (ARRY-558) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

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A PHASE 1, OPEN-LABEL, MULTI-CENTER, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY EVIDENCE OF ANTI-TUMOR ACTIVITY OF PF-07284892 (ARRY-558) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 06 May 2024

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At a glance

  • Drugs Binimetinib (Primary) ; Cetuximab (Primary) ; Encorafenib (Primary) ; Lorlatinib (Primary) ; PF-07284892 (Primary)
  • Indications Colorectal cancer; Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Pfizer

    • Most Recent Events

    • 26 Apr 2024 Planned primary completion date changed from 4 Jun 2024 to 18 Jun 2024.
    • 01 Apr 2024 Planned primary completion date changed from 29 Apr 2024 to 4 Jun 2024.
    • 30 Nov 2023 Planned End Date changed from 4 Dec 2025 to 29 Nov 2025.

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