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A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered FHD-286 in Subjects With Metastatic Uveal Melanoma

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Trial Profile

A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered FHD-286 in Subjects With Metastatic Uveal Melanoma

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 12 Aug 2024

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At a glance

  • Drugs FHD-286 (Primary)
  • Indications Uveal melanoma
  • Focus Adverse reactions; First in man
  • Sponsors Foghorn Therapeutics

    • Most Recent Events

    • 08 Aug 2024 According to a Foghorn Therapeutics media release, research and development expenses were $23.8 million for the three months ended June 30, 2024, compared to $29.2 million for the three months ended June 30, 2023. This decrease was primarily due to lower personnel-related costs and lower development program spend following the shutdown of two clinical studies (FHD-286 in metastatic uveal melanoma and FHD-609 (BRD9 degrader) in synovial sarcoma).
    • 23 Apr 2024 Status changed from active, no longer recruiting to discontinued.
    • 13 Oct 2023 According to a Foghorn Therapeutics media release, clinical data from the dose escalation and expansion study of FHD-286 will be presented at the ESMO Congress 2023, to be held October 20-24 in Madrid, Spain.

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