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A Phase 1, Multicenter, Open-Label, Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered FHD-286, as Monotherapy or Combination Therapy, in Subjects With Advanced Hematologic Malignancies

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Trial Profile

A Phase 1, Multicenter, Open-Label, Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered FHD-286, as Monotherapy or Combination Therapy, in Subjects With Advanced Hematologic Malignancies

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 08 Apr 2025

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At a glance

  • Drugs FHD-286 (Primary) ; Cytarabine; Decitabine
  • Indications Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Haematological malignancies; Myelodysplastic syndromes
  • Focus Adverse reactions; First in man
  • Sponsors Foghorn Therapeutics

Most Recent Events

  • 16 Dec 2024 According to a Foghorn Therapeutics media release, company expects to report the results at a medical conference in 2025.
  • 16 Dec 2024 Status changed from recruiting to discontinued because the observed response rate did not meet the threshold to continue development by Foghorn alone as per a Foghorn Therapeutics media release.
  • 04 Nov 2024 According to a Foghorn Therapeutics media release, topline safety, tolerability, initial efficacy, and PK/PD data expected by year-end 2024

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