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A Phase 1b Randomized, Blinded, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Broadly Neutralizing Antibodies (bNAbs) GS-5423 and GS-2872 in Combination With Capsid Inhibitor Lenacapavir (GS-6207) in Virologically Suppressed Adults With HIV-1 Infection

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Trial Profile

A Phase 1b Randomized, Blinded, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Broadly Neutralizing Antibodies (bNAbs) GS-5423 and GS-2872 in Combination With Capsid Inhibitor Lenacapavir (GS-6207) in Virologically Suppressed Adults With HIV-1 Infection

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 19 Apr 2024

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At a glance

  • Drugs Lenacapavir (Primary) ; Lenacapavir (Primary) ; Teropavimab (Primary) ; Zinlirvimab (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Proof of concept
  • Sponsors Gilead Sciences
  • Most Recent Events

    • 06 Mar 2024 Results (n=11) assessing safety & efficacy of LEN+TAB+ZAB for maintenance of VS in a cohort of participants who met viral sensitivity criteria to either TAB or ZAB, presented at the 31st Conference on Retroviruses and Opportunistic Infections 2024
    • 05 Mar 2024 According to a Gilead Sciences media release, data from this study were published in The Lancet HIV.
    • 05 Mar 2024 Results published in the Gilead Sciences Media Release.

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