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A Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy

Trial Profile

A Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Non-obstructive Hypertrophic Cardiomyopathy

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 25 Apr 2024

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At a glance

  • Drugs Ninerafaxstat (Primary)
  • Indications Hypertrophic cardiomyopathy
  • Focus Adverse reactions; Proof of concept
  • Acronyms IMPROVE-HCM
  • Sponsors Imbria Pharmaceuticals

Most Recent Events

  • 22 Apr 2024 Status changed from active, no longer recruiting to completed.
  • 08 Apr 2024 According to an Imbria Pharmaceuticals media release, results from this trial support initiation of the Phase 3 FORTITUDE-HCM clinical trial of ninerafaxstat in patients with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
  • 08 Apr 2024 According to an Imbria Pharmaceuticals media release, results from the Phase 2 IMPROVE-HCM clinical trial were presented in a late-breaking clinical trial session at the American College of Cardiology Annual Scientific Session & Expo (ACC.24) and published in the Journal of the American College of Cardiology (JACC).

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