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An Open-Label, Multicenter, Phase Ib Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290, A Fibroblast Activation Protein-A (FAP) Targeted 4-1BB Ligand (CD137L), In Combination With Cibisatamab With Obinutuzumab Pre-Treatment, In Participants With Previously Treated, Metastatic, Microsatellite-stable Colorectal Adenocarcinoma With High CEACAM5 Expression

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Trial Profile

An Open-Label, Multicenter, Phase Ib Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290, A Fibroblast Activation Protein-A (FAP) Targeted 4-1BB Ligand (CD137L), In Combination With Cibisatamab With Obinutuzumab Pre-Treatment, In Participants With Previously Treated, Metastatic, Microsatellite-stable Colorectal Adenocarcinoma With High CEACAM5 Expression

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 08 Jan 2025

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At a glance

  • Drugs Cibisatamab (Primary) ; Obinutuzumab (Primary) ; RG 7827 (Primary)
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Rectal cancer
  • Focus Adverse reactions
  • Sponsors Roche

Most Recent Events

  • 06 Jan 2025 Status changed from active, no longer recruiting to completed.
  • 12 Mar 2024 Planned End Date changed from 31 Jul 2025 to 27 Dec 2024.
  • 12 Mar 2024 Planned primary completion date changed from 31 Jul 2025 to 27 Dec 2024.

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