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A Phase Ib, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-Mutant Advanced Melanoma Who Have Received Anti-PD-1/PD-L1 Therapy

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Trial Profile

A Phase Ib, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-Mutant Advanced Melanoma Who Have Received Anti-PD-1/PD-L1 Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Feb 2026

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At a glance

Most Recent Events

  • 03 Feb 2026 Planned End Date changed from 31 Dec 2025 to 30 Jun 2027.
  • 03 Feb 2026 Planned primary completion date changed from 31 Dec 2025 to 30 Jun 2027.
  • 30 Sep 2025 Planned End Date changed from 28 Nov 2025 to 31 Dec 2025.

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