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A Phase Ib, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-Mutant Advanced Melanoma Who Have Received Anti-PD-1/PD-L1 Therapy

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A Phase Ib, Open-Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-Mutant Advanced Melanoma Who Have Received Anti-PD-1/PD-L1 Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Mar 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Belvarafenib (Primary) ; Cobimetinib (Primary)
  • Indications Malignant melanoma
  • Focus Adverse reactions
  • Sponsors Genentech

    • Most Recent Events

    • 15 Feb 2024 Status changed from recruiting to active, no longer recruiting.
    • 01 Dec 2023 Planned End Date changed from 1 Sep 2024 to 28 Nov 2025.
    • 01 Dec 2023 Planned primary completion date changed from 6 Nov 2023 to 28 Nov 2025.

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