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A Phase 1 Randomized, Double Blind, Placebo Controlled, Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CT-388 in Otherwise Healthy Overweight and Obese Adult Participants and in Obese Patients With Type 2 Diabetes Mellitus

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Trial Profile

A Phase 1 Randomized, Double Blind, Placebo Controlled, Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CT-388 in Otherwise Healthy Overweight and Obese Adult Participants and in Obese Patients With Type 2 Diabetes Mellitus

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 26 Sep 2024

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At a glance

  • Drugs CT-388 (Primary)
  • Indications Obesity; Type 2 diabetes mellitus
  • Focus Adverse reactions; First in man
  • Sponsors Carmot Therapeutics; Roche

    • Most Recent Events

    • 19 Sep 2024 Status changed from recruiting to completed.
    • 16 May 2024 Results presented in the Genentech Media Release.
    • 16 May 2024 According to a Roche media release, an additional cohort from the ongoing placebo-controlled Phase I trial of CT-388 will evaluate obese patients (BMI>30 kg/m2) with type 2 diabetes over a 12-week treatment duration. Roche expects data from this additional cohort in the second half of 2024.

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