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A Phase II Randomized Study Comparing Ibrutinib and Rituximab vs. Venetoclax and Rituximab in Previously Untreated Waldenstrom's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

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Trial Profile

A Phase II Randomized Study Comparing Ibrutinib and Rituximab vs. Venetoclax and Rituximab in Previously Untreated Waldenstrom's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

Status: Suspended
Phase of Trial: Phase II

Latest Information Update: 10 Dec 2025

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At a glance

  • Drugs Ibrutinib (Primary) ; Rituximab (Primary) ; Venetoclax (Primary)
  • Indications Waldenstrom's macroglobulinaemia
  • Focus Therapeutic Use

Most Recent Events

  • 25 Nov 2025 Status changed from recruiting to suspended. Reason the study was stopped: Other - For RRA for Venetoclax issued 10/17/2025
  • 05 Apr 2024 Planned End Date changed from 30 Apr 2024 to 31 Mar 2028.
  • 05 Apr 2024 Planned primary completion date changed from 30 Apr 2024 to 31 Mar 2028.

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