Trial Profile

A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 11 Mar 2026

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At a glance

Drugs Ibrutinib (Primary) ; Rituximab (Primary) ; Venetoclax (Primary) ; Zanubrutinib (Primary)
Indications Waldenstrom's macroglobulinaemia
Focus Therapeutic Use

04 Mar 2026 Status changed from suspended to recruiting.
03 Mar 2026 Zanubrutinib is added to Active Comparator arm.
25 Nov 2025 Status changed from recruiting to suspended. Reason the study was stopped: Other - For RRA for Venetoclax issued 10/17/2025

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