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A Phase 1/2, Open-label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab (Phase 1 and Phase 2) and Pembrolizumab and Pegylated Liposomal Doxorubicin (Phase 1b) in Patients With Platinum Resistant or Refractory Ovarian Cancer

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Trial Profile

A Phase 1/2, Open-label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab (Phase 1 and Phase 2) and Pembrolizumab and Pegylated Liposomal Doxorubicin (Phase 1b) in Patients With Platinum Resistant or Refractory Ovarian Cancer

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 15 May 2025

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At a glance

Most Recent Events

  • 13 May 2025 According to a TILT Biotherapeutics media release, company excited to have already opened the first site in the USA and are looking forward to dosing our first patients soon and opening at least five more sites this year.
  • 13 May 2025 According to a TILT Biotherapeutics media release Interim results from ongoing Phase 1b trials are expected to read out in H2 2026.
  • 13 May 2025 According to a TILT Biotherapeutics media release, company announced that it has raised USD 25.6 million (EUR 22.6 million) in a Series B financing, will support a Phase 2 clinical trial of Tiltbios lead product, TILT-123, in patients with platinum-resistant epithelial ovarian cancer.

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