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An Open-label Study to Evaluate the Drug-drug Interaction Effect of Rifampin, a CYP3A4 Inducer, on the Pharmacokinetics of AMG 510 in Healthy Subjects

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Trial Profile

An Open-label Study to Evaluate the Drug-drug Interaction Effect of Rifampin, a CYP3A4 Inducer, on the Pharmacokinetics of AMG 510 in Healthy Subjects

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 20 Oct 2022

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At a glance

  • Drugs Sotorasib (Primary) ; Rifampicin
  • Indications Brain metastases; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Pharmacokinetics
  • Sponsors Amgen

    • Most Recent Events

    • 21 Apr 2021 New trial record
    • 17 Mar 2021 Results presented at the 122nd Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics

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