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A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of Autologous CD34+ Base Edited Hematopoietic Stem Cells (BEAM-101) to Increase Fetal Hemoglobin (HbF) Production in Patients With Severe Sickle Cell Disease

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Trial Profile

A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of Autologous CD34+ Base Edited Hematopoietic Stem Cells (BEAM-101) to Increase Fetal Hemoglobin (HbF) Production in Patients With Severe Sickle Cell Disease

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 15 Mar 2024

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At a glance

  • Drugs BEAM 101 (Primary)
  • Indications Sickle cell anaemia
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms BEACON
  • Sponsors Beam Therapeutics
  • Most Recent Events

    • 08 Aug 2023 According to the Beam Therapeutics media release, the company continues to anticipate reporting initial data on multiple patients from the BEACON trial in 2024.
    • 08 Aug 2023 According to the Beam Therapeutics media release, the company has continued to consent additional patients and anticipates that currently consented patients are sufficient to both fill the sentinel cohort (n=3) and to initiate the expansion cohort. The company will continue adding additional patients to the BEACON trial through the end of year and beyond, with a total target of 45 treated patients.
    • 08 Aug 2023 According to the Beam Therapeutics media release, the first patient having been consented and dosing expected this quarter.
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