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A Phase 3 Clinical Trial to Confirm Efficacy and Evaluate Safety of Twice-daily Delgocitinib Cream 20 mg/g Compared With Cream Vehicle for a 16-week Treatment Period in Adult Subjects With Moderate to Severe Chronic Hand Eczema (DELTA 2)

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Trial Profile

A Phase 3 Clinical Trial to Confirm Efficacy and Evaluate Safety of Twice-daily Delgocitinib Cream 20 mg/g Compared With Cream Vehicle for a 16-week Treatment Period in Adult Subjects With Moderate to Severe Chronic Hand Eczema (DELTA 2)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 18 Nov 2025

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At a glance

  • Drugs Delgocitinib (Primary)
  • Indications Eczema
  • Focus Registrational; Therapeutic Use
  • Acronyms DELTA 2
  • Sponsors LEO Pharma

Most Recent Events

  • 05 Nov 2025 According to a Leo Pharma media release, based on robust clinical evidence from the DELTA 1, 2, 3 and DELTA FORCE trials, the National Institute for Health and Care Excellence (NICE) has issued Technology Appraisal Guidance (TAG) recommending the reimbursement of Anzupgo (delgocitinib) cream for the treatment of adult patients with moderate to severe chronic hand eczema (CHE), for whom topical corticosteroids are inadequate or inappropriate.
  • 21 Oct 2025 According to a Leo Pharma media release, data from this trial will be presented at the upcoming 2025 Fall Clinical Dermatology Conference
  • 26 Aug 2025 According to a LEO Pharma media release, based on the results from the DELTA 1 and DELTA 2 Clinical trials ,Health Canada has approved Anzupgo for the treatment of adult patients with moderate to severe chronic hand eczema

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