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A Phase I Study of Entrectinib in Combination With ASTX727 (35 mg Decitabine and 100 mg Cedazuridine) in Patients With Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia (AML)

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Trial Profile

A Phase I Study of Entrectinib in Combination With ASTX727 (35 mg Decitabine and 100 mg Cedazuridine) in Patients With Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia (AML)

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 25 May 2026

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At a glance

  • Drugs Cedazuridine/decitabine (Primary) ; Entrectinib
  • Indications Acute myeloid leukaemia; Breast cancer; Chronic myelomonocytic leukaemia; Glioma; Myelodysplastic syndromes; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 27 Apr 2026 Planned End Date changed from 30 Jun 2026 to 31 Dec 2026.
  • 20 Oct 2025 Status changed from suspended to active, no longer recruiting.
  • 15 Jun 2025 Status changed from recruiting to suspended.

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