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ctDNA-guided Adaptive Therapy Escalation in ER+ MBC: A Phase 1b Study With Letrozole, Palbociclib and Onapristone ER

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Trial Profile

ctDNA-guided Adaptive Therapy Escalation in ER+ MBC: A Phase 1b Study With Letrozole, Palbociclib and Onapristone ER

Status: Withdrawn prior to enrolment
Phase of Trial: Phase I/II

Latest Information Update: 02 May 2023

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At a glance

  • Drugs Onapristone (Primary) ; Letrozole; Palbociclib
  • Indications Advanced breast cancer
  • Focus Adverse reactions

    • Most Recent Events

    • 26 Apr 2023 Status changed from recruiting to withdrawn prior to enrolment. The sponsor closed the study due to discontinuing their onapristone program.
    • 10 Dec 2022 Trial design presented at the 45th Annual San Antonio Breast Cancer Symposium
    • 11 Aug 2022 According to a Context Therapeutics media release, enrollment continues primarily due to slower than anticipated patient enrollment and preliminary data from the Phase 1b portion of the trial is expected in mid 2023.
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