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A Phase 1b, Open Label, Global, Multicenter, Dose Determination, Randomized Dose Expansion Study to Determine the Maximum Tolerated Dose, Assess the Safety and Tolerability, Pharmacokinetics and Preliminary Efficacy of Iberdomide (CC-220) in Combination With R-CHOP-21 and CC-99282 in Combination With R-CHOP-21 for Subjects With Previously Untreated, Aggressive B-cell Lymphoma

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Trial Profile

A Phase 1b, Open Label, Global, Multicenter, Dose Determination, Randomized Dose Expansion Study to Determine the Maximum Tolerated Dose, Assess the Safety and Tolerability, Pharmacokinetics and Preliminary Efficacy of Iberdomide (CC-220) in Combination With R-CHOP-21 and CC-99282 in Combination With R-CHOP-21 for Subjects With Previously Untreated, Aggressive B-cell Lymphoma

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Sep 2024

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At a glance

  • Drugs Golcadomide (Primary) ; Iberdomide (Primary) ; Polatuzumab vedotin (Primary) ; Cyclophosphamide; Doxorubicin; Prednisone; Prednisone; Rituximab; Rituximab; Vincristine
  • Indications B-cell lymphoma
  • Focus Adverse reactions
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 04 Sep 2024 Planned primary completion date changed from 31 Jul 2024 to 30 Sep 2024.
    • 23 Jul 2024 Planned primary completion date changed from 10 Jun 2024 to 31 Jul 2024.
    • 12 Dec 2023 Results presented at the 65th American Society of Hematology Annual Meeting and Exposition

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