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A Two-cohort, Two-part, Phase 1, Multicenter, Open-label, Fixed-sequence, Drug-Drug Interaction and QTc Assessments of Sitravatinib Followed by Combination Treatment With Nivolumab in Patients With Advanced Solid Malignancies

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A Two-cohort, Two-part, Phase 1, Multicenter, Open-label, Fixed-sequence, Drug-Drug Interaction and QTc Assessments of Sitravatinib Followed by Combination Treatment With Nivolumab in Patients With Advanced Solid Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 14 May 2024

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At a glance

  • Drugs Nivolumab (Primary) ; Sitravatinib (Primary) ; Dextromethorphan; Digoxin; Midazolam; Rosuvastatin; Warfarin
  • Indications Solid tumours
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Mirati Therapeutics

    • Most Recent Events

    • 19 Oct 2023 Status changed from active, no longer recruiting to completed.
    • 27 Jan 2023 Planned End Date changed from 1 Dec 2023 to 23 Dec 2023.
    • 27 Jan 2023 Planned primary completion date changed from 1 Jun 2023 to 23 Jun 2023.

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