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Phase I/II 225Ac-J591 Plus 177Lu-PSMA-I&T for Progressive Metastatic Castration Resistant Prostate Cancer

Trial Profile

Phase I/II 225Ac-J591 Plus 177Lu-PSMA-I&T for Progressive Metastatic Castration Resistant Prostate Cancer

Status: Suspended
Phase of Trial: Phase I/II

Latest Information Update: 23 Aug 2023

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At a glance

  • Drugs ATL 101 Telix Pharmaceuticals (Primary) ; Lutetium-177-PSMA-imaging-and-therapy (Primary)
  • Indications Adenocarcinoma; Bone metastases; Liver metastases; Prostate cancer
  • Focus Adverse reactions
  • Most Recent Events

    • 15 Aug 2023 Planned number of patients changed from 33 to 48.
    • 27 Jul 2023 Status changed from recruiting to suspended.
    • 06 Jun 2023 Results (of phase I dose-escalation, n=18 ) assessing safety of of prostate-specific membrane antigen-targeted radionuclide therapy (PSMA-TRT) with alpha-radiolabeled antibody 225Ac-J591 and beta-radioligand 177Lu-PSMA I&T presented at the 59th Annual Meeting of the American Society of Clinical Oncology
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