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A Two-Part Study of REC-994 in the Treatment of Adults With Symptomatic Cerebral Cavernous Malformation (CCM); Part 1: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Two Doses of REC-994; Part 2: A Long-Term Blinded Extension Clinical Trial to Evaluate Long-Term Safety Tolerability and Efficacy of REC-994

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A Two-Part Study of REC-994 in the Treatment of Adults With Symptomatic Cerebral Cavernous Malformation (CCM); Part 1: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Two Doses of REC-994; Part 2: A Long-Term Blinded Extension Clinical Trial to Evaluate Long-Term Safety Tolerability and Efficacy of REC-994

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 25 Nov 2024

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At a glance

  • Drugs Tempol (Primary)
  • Indications Central nervous system cavernous haemangioma
  • Focus Adverse reactions; Proof of concept
  • Acronyms SYCAMORE
  • Sponsors Recursion Pharmaceuticals

    • Most Recent Events

    • 20 Nov 2024 According to a Recursion Pharmaceuticals media release, Further data to be shared at an upcoming medical conference / publication / webinar in H1 2025; regulatory update expected by H2 2025
    • 03 Sep 2024 Results published in the Recursion Pharmaceuticals Media Release.
    • 03 Sep 2024 According to a Recursion Pharmaceuticals media release, Dr, Jan-Karl Burkhardt, MD, is Principal Investigator of this study. The company plans to present data from this trial at a forthcoming medical conference and intends to submit these data for publication in a peer reviewed scientific journal. A meeting with the FDA is anticipated as soon as practical to discuss plans for an additional clinical study.

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