Trial Profile

Phase II Study of Dual Targeting of CD19 and CD20 Antigens Using Sequential CD19-directed 4-1BB-CD3ζ CAR-T Cells Followed by Mosunetuzumab or Glofitamab in Relapsed or Refractory Diffuse Large B-cell or Transformed Follicular Lymphomas

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 05 Jun 2026

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At a glance

Drugs Glofitamab (Primary) ; Mosunetuzumab (Primary) ; Obinutuzumab (Primary)
Indications B-cell lymphoma; Diffuse large B cell lymphoma
Focus Adverse reactions; Therapeutic Use

26 May 2026 Planned number of patients changed from 42 to 23.
18 Mar 2026 Planned End Date changed from 30 Jun 2027 to 31 Dec 2028.
18 Mar 2026 Planned primary completion date changed from 30 Jun 2026 to 31 Dec 2027.

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