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A Phase 1/2, First-in-Human, Open Label, Dose Escalation and Expansion Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

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A Phase 1/2, First-in-Human, Open Label, Dose Escalation and Expansion Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 14 Aug 2024

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At a glance

  • Drugs Aldesleukin (Primary) ; AU-007 (Primary)
  • Indications Bladder cancer; Cancer; Colorectal cancer; Head and neck cancer; Malignant melanoma; Merkel cell carcinoma; Nasopharyngeal cancer; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours; Urogenital cancer
  • Focus Adverse reactions; First in man
  • Sponsors Aulos Bioscience

    • Most Recent Events

    • 18 Jul 2024 Planned number of patients changed from 136 to 159.
    • 04 Jun 2024 Updated results presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 30 May 2024 Planned End Date changed from 31 Jan 2025 to 30 Sep 2025.

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