Trial Profile

A Phase I, Dose Escalation and Dose Expansion, Safety and Tolerability Study of onCARlytics (CF33-CD19), Administered Intravenously or Intratumorally in Combination With Blinatumomab in Adults With Advanced or Metastatic Solid Tumors (OASIS)

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 10 Mar 2026

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At a glance

Drugs Blinatumomab (Primary) ; Hydroxycarbamide (Primary) ; OnCARlytics (Primary) ; OnCARlytics (Primary)
Indications Advanced breast cancer; Cholangiocarcinoma; Malignant melanoma; Ovarian cancer; Solid tumours
Focus Adverse reactions
Acronyms OASIS
Sponsors Imugene

06 Mar 2026 Status changed from active, no longer recruiting to discontinued.
18 Dec 2025 Status changed from recruiting to active, no longer recruiting.
09 Apr 2025 Trial arms increased from 4 to 6. Drug Hydroxyurea added newly to the interventional arms.

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