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A Phase I and Expansion Cohort Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

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Trial Profile

A Phase I and Expansion Cohort Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 03 Feb 2026

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At a glance

  • Drugs Cytarabine (Primary) ; Cytarabine (Primary) ; Filgrastim (Primary) ; Fludarabine (Primary) ; Hydrocortisone (Primary) ; Methotrexate (Primary) ; Selinexor (Primary) ; Venetoclax (Primary)
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia
  • Focus Adverse reactions
  • Acronyms SELCLAX

Most Recent Events

  • 26 Jan 2026 Planned End Date changed from 1 Feb 2026 to 1 Sep 2027.
  • 16 Oct 2025 Planned End Date changed from 1 Jun 2027 to 1 Feb 2026.
  • 25 Jun 2025 Status changed from suspended to active, no longer recruiting.

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