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A Phase I and Expansion Cohort Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

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Trial Profile

A Phase I and Expansion Cohort Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 09 Sep 2024

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At a glance

  • Drugs Cytarabine (Primary) ; Cytarabine (Primary) ; Filgrastim (Primary) ; Fludarabine (Primary) ; Hydrocortisone (Primary) ; Methotrexate (Primary) ; Selinexor (Primary) ; Venetoclax (Primary)
  • Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia
  • Focus Adverse reactions
  • Acronyms SELCLAX

    • Most Recent Events

    • 16 Jan 2024 Planned End Date changed from 1 Jun 2024 to 1 Jul 2025.
    • 12 Dec 2023 Results (As of July 14, 2023, n=15) presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 23 Jan 2023 Planned End Date changed from 1 Jun 2023 to 1 Jun 2024.

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