A Global, Phase 1/2, Open-Label, Dose Optimization Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of mRNA-3705 in Participants With Isolated Methylmalonic Acidemia Due to Methylmalonyl-CoA Mutase Deficiency
Latest Information Update: 20 Dec 2024
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At a glance
- Drugs MRNA-3705 (Primary)
- Indications Methylmalonic acidaemia
- Focus Adverse reactions; First in man
- Acronyms Landmark study
- Sponsors Moderna Therapeutics
- 31 Oct 2023 Planned number of patients changed from 33 to 63.
- 16 Aug 2021 According to a Moderna media release, the company announced the first patient has been dosed in this trial.
- 02 Aug 2021 Planned initiation date (estimated date for recruitment of the first subject) changed from 28 Jun 2021 to 6 Aug 2021.