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A Phase 1/1b, Three-Part, Randomised, Placebo-Controlled, Single- and Multiple-Ascending-Dose Study to Evaluate the Safety, Pharmacokinetics, and Activity of SZN-1326 in Healthy Volunteers and in Subjects with Moderate to Severe Ulcerative Colitis

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Trial Profile

A Phase 1/1b, Three-Part, Randomised, Placebo-Controlled, Single- and Multiple-Ascending-Dose Study to Evaluate the Safety, Pharmacokinetics, and Activity of SZN-1326 in Healthy Volunteers and in Subjects with Moderate to Severe Ulcerative Colitis

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 25 Jan 2024

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At a glance

  • Drugs SZN-1326 (Primary) ; SZN-1326 (Primary)
  • Indications Ulcerative colitis
  • Focus Adverse reactions; First in man
  • Sponsors Surrozen

Most Recent Events

  • 25 Jan 2024 Status changed from recruiting to discontinued.
  • 18 Jan 2024 According to Surrozen media release, the decision to discontinue SZN-1326 was based on the challenges of identifying a safe and potentially effective dose along with strategic considerations including the significant clinical development expenses and market competition in IBD.
  • 18 Jan 2024 According to Surrozen media release, following the completion of the Phase 1 single ascending dose clinical trial for SZN-1326, company will discontinue development of SZN-1326 in inflammatory bowel disease (IBD). SZN-1326 has been evaluated in a Phase 1 single ascending dose clinical trial in 37 healthy volunteers in doses ranging from 0.01mg to 25mg.

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