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A Phase 1b/2 Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib (LANRA) in Combination With the FLT3 Inhibitor Gilteritinib, in Patients With FLT3-mutated Relapsed or Refractory AML

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Trial Profile

A Phase 1b/2 Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib (LANRA) in Combination With the FLT3 Inhibitor Gilteritinib, in Patients With FLT3-mutated Relapsed or Refractory AML

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 09 Aug 2024

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At a glance

  • Drugs Gilteritinib (Primary) ; Lanraplenib (Primary)
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions
  • Sponsors Kronos Bio

    • Most Recent Events

    • 19 Apr 2024 Status changed from active, no longer recruiting to discontinued as per sponsor's decision.
    • 14 Mar 2024 This trial has been Discontinued in Spain, according to European Clinical Trials Database record.
    • 27 Dec 2023 Planned primary completion date changed from 1 Nov 2023 to 1 May 2024.

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