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A Multi-arm, Phase II, Open-Label, Multicentre Study to Assess the Preliminary Efficacy of RXC004 in Monotherapy and in Combination With Nivolumab, in Patients With Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer Who Have Progressed Following Therapy With Current Standard of Care (PORCUPINE)

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A Multi-arm, Phase II, Open-Label, Multicentre Study to Assess the Preliminary Efficacy of RXC004 in Monotherapy and in Combination With Nivolumab, in Patients With Ring Finger Protein 43 (RNF43) or R-spondin (RSPO) Aberrated, Metastatic, Microsatellite Stable, Colorectal Cancer Who Have Progressed Following Therapy With Current Standard of Care (PORCUPINE)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 08 May 2024

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At a glance

  • Drugs Nivolumab (Primary) ; RXC 004 (Primary) ; Denosumab
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms PORCUPINE
  • Sponsors Redx Pharma

    • Most Recent Events

    • 01 May 2024 Status changed from recruiting to completed.
    • 16 Mar 2023 Planned End Date changed from 1 Aug 2023 to 1 Dec 2023.
    • 16 Mar 2023 Planned primary completion date changed from 1 Apr 2023 to 1 Aug 2023.

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