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A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Investigational Agents as Monotherapy or in Combination With Pembrolizumab for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line Therapy (KEYNOTE-B98)

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A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Investigational Agents as Monotherapy or in Combination With Pembrolizumab for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line Therapy (KEYNOTE-B98)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 05 Dec 2024

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At a glance

  • Drugs Favezelimab/pembrolizumab (Primary) ; Lenvatinib (Primary) ; MK-4830 (Primary) ; Pembrolizumab/Quavonlimab (Primary)
  • Indications Small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms KEYNOTE-B98
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 10 Nov 2024 Planned End Date changed from 19 Nov 2029 to 10 Dec 2029.
    • 16 Oct 2024 Treatment arms has been added hence treatment arms changed from 4 to 5, hence patient number was changed from 80 to 110.
    • 16 Oct 2024 Planned number of patients changed from 80 to 110.

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