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A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Investigational Agents for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line Therapy (KEYNOTE-B98)

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Trial Profile

A Phase 1b/2 Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Investigational Agents for the Treatment of Participants With PD-1/L1-refractory Extensive-Stage Small Cell Lung Cancer in Need of Second-Line Therapy (KEYNOTE-B98)

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 25 Apr 2024

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At a glance

  • Drugs Favezelimab/pembrolizumab (Primary) ; Lenvatinib (Primary) ; MK-4830 (Primary) ; Pembrolizumab/Quavonlimab (Primary)
  • Indications Small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms KEYNOTE-B98
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.
  • Most Recent Events

    • 02 Jan 2023 Status changed from recruiting to active, no longer recruiting.
    • 21 Jul 2021 Status changed from not yet recruiting to recruiting.
    • 21 Jul 2021 Planned initiation date (estimated date of first participant enrollement) changed from 16 Jul 2021 to 6 Aug 2021.

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