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A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Ciltacabtagene Autoleucel, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy

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Trial Profile

A Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Ciltacabtagene Autoleucel, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 13 Mar 2026

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At a glance

  • Drugs Bortezomib (Primary) ; Ciltacabtagene autoleucel (Primary) ; Cyclophosphamide (Primary) ; Dexamethasone (Primary) ; Fludarabine (Primary) ; Lenalidomide (Primary)
  • Indications Multiple myeloma
  • Focus Registrational; Therapeutic Use
  • Acronyms CARTITUDE-5
  • Sponsors Janssen Research & Development; Janssen-Cilag

Most Recent Events

  • 13 Mar 2026 New source identified and integrated Clinical Trials Information System (CTIS2023-505850-16-00)
  • 09 Aug 2024 According to a Legend Biotech USA media release, this trial Completed enrollment in July 2024.
  • 09 Aug 2024 According to a Legend Biotech USA media release, Status changed from recruiting to active, no longer recruiting.

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