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Efficacy and Safety of Aumolertinib With or Without Chemotherapy as First-line Treatment in Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Sensitizing Epidermal Growth Factor Receptor Mutations: A Randomized, Controlled, Open-label, Phase 3 and Multicenter Clinical Study

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Trial Profile

Efficacy and Safety of Aumolertinib With or Without Chemotherapy as First-line Treatment in Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Sensitizing Epidermal Growth Factor Receptor Mutations: A Randomized, Controlled, Open-label, Phase 3 and Multicenter Clinical Study

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Aumolertinib (Primary) ; Carboplatin; Cisplatin; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms AENEAS2
  • Sponsors Jiangsu Hansoh Pharmaceutical

Most Recent Events

  • 30 Apr 2025 Primary endpoint has been met. (PFS (Progression Free Survival) assessed by IRC (Independent Review Committee))
  • 30 Apr 2025 Results (at data cutoff 2024/06/18) assessing aumolertinib with or without chemotherapy as first line treatment in locally advanced or metastatic NSCLC with sensitizing EGFR mutations were presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 25 Nov 2024 Status changed from recruiting to active, no longer recruiting.

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