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A Phase 3 Randomized, Double-Blind, Decentralized Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in the Treatment of Patients With COL3A1-Positive Vascular Ehlers-Danlos Syndrome

Trial Profile

A Phase 3 Randomized, Double-Blind, Decentralized Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in the Treatment of Patients With COL3A1-Positive Vascular Ehlers-Danlos Syndrome

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 15 May 2025

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At a glance

  • Drugs Celiprolol (Primary)
  • Indications Ehlers-Danlos syndrome
  • Focus Registrational; Therapeutic Use
  • Acronyms DiSCOVER
  • Sponsors Acer Therapeutics

Most Recent Events

  • 08 May 2025 According to a Zevra Therapeutics media release, 5 additional patients enrolled in the Phase 3 DiSCOVER trial of celiprolol for the treatment of Vascular Ehlers-Danlos Syndrome, bringing the total number of enrolled patients to 32.
  • 07 Apr 2025 According to a Zevra Therapeutics media release, company announced the closing of the sale of its Rare Pediatric Disease Priority Review Voucher (PRV) for gross proceeds of $150 million. The $150 million in gross proceeds is non-dilutive capital that will ongoing Phase 3 trial for celiprolol.
  • 11 Mar 2025 According to a Zevra Therapeutics media release, as of Dec. 31, 2024, eight additional patients enrolled in the Phase 3 DiSCOVER trial of celiprolol for the treatment of Vascular Ehlers-Danlos Syndrome (VEDS), bringing the total patients enrolled to 27.

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