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A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination With Immuno-Oncology or Other Agents in Subjects With Unresectable Advanced or Metastatic Solid Tumors

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Trial Profile

A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination With Immuno-Oncology or Other Agents in Subjects With Unresectable Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 12 Aug 2026

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At a glance

  • Drugs Bempegaldesleukin (Primary) ; Docetaxel (Primary) ; Ipilimumab (Primary) ; Nivolumab (Primary) ; Nivolumab/relatlimab (Primary) ; Prednisone (Primary) ; Relatlimab (Primary) ; Zanzalintinib (Primary)
  • Indications Adenocarcinoma; Carcinoma; Colorectal cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Prostate cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Transitional cell carcinoma; Urogenital cancer
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Acronyms STELLAR-002
  • Sponsors Exelixis

Most Recent Events

  • 05 Aug 2026 Number of arms changed from 7 to 9. Allocation changed to Randomized. Experimental: Zanzalintinib + Docetaxel + Prednisone Dose Expansion Cohort and Experimental: Zanzalintinib + DDI Probe Substrates Dose Expansion Cohort added to study protocol. Planned number of patients also increased. Primary and secondary outcome measures updated.
  • 05 Aug 2026 Planned number of patients changed from 1314 to 1394.
  • 05 Aug 2026 Planned primary completion date changed from 28 Jun 2030 to 31 Jan 2027.

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