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A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

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Trial Profile

A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 09 Oct 2025

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At a glance

  • Drugs Pevifoscorvir sodium (Primary) ; Tenofovir disoproxil fumarate
  • Indications Hepatitis B
  • Focus Therapeutic Use
  • Acronyms B-SUPREME
  • Sponsors Aligos Therapeutics

Most Recent Events

  • 06 Aug 2025 According to an Aligos Therapeutics media release, initiation of this Phase 2 B-SUPREME study of ALG-000184 is well underway with regulatory approvals across a number of countries, including the US, China, Canada, Taiwan, UK, New Zealand, and Moldova. Site activations are in progress, subjects are being screened, and we expect dosing to commence in the coming weeks.
  • 29 Jul 2025 Status changed from not yet recruiting to recruiting.
  • 09 May 2025 Status changed from planning to not yet recruiting.

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