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A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

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Trial Profile

A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 21 Aug 2026

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At a glance

  • Drugs Pevifoscorvir sodium (Primary) ; Tenofovir disoproxil fumarate
  • Indications Hepatitis B
  • Focus Therapeutic Use
  • Acronyms B-SUPREME
  • Sponsors Aligos Therapeutics

Most Recent Events

  • 13 Jul 2026 According to an Aligos Therapeutics media release,announced that it has completed enrollment of both the HBeAg+ (Part 1a) and HBeAg- (Part 2a) participants in the Phase 2 B-SUPREME study of pevifoscorvir sodium, under development for the treatment of chronic hepatitis B virus (HBV) infection. Topline safety and efficacy data are expected to be available in late third quarter of 2027.
  • 13 Jul 2026 Status changed from recruiting to active, no longer recruiting, according to a Aligos Therapeutics media release.
  • 13 May 2026 According to an Aligos Therapeutics media release, the data from the trial will be presented at the European Association for the Study of the Liver (EASL) Congress 2026.

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