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A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

Trial Profile

A Randomized, Double-Blind, Active-Controlled Multicenter Phase 2 Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg-Negative Adult Subjects With Chronic Hepatitis B Virus Infection (B-SUPREME)

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 17 May 2025

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At a glance

  • Drugs ALG-000184 (Primary) ; Tenofovir disoproxil fumarate
  • Indications Hepatitis B
  • Focus Therapeutic Use
  • Acronyms B-SUPREME
  • Sponsors Aligos Therapeutics

Most Recent Events

  • 09 May 2025 Status changed from planning to not yet recruiting.
  • 06 May 2025 According to Aligos Therapeutics media release, the company has raised over $100M to begin this trial. The interim data for this study is expected in 2026 and topline data anticipated in 2027.
  • 10 Mar 2025 According to an Aligos Therapeutics media release, Phase 2 study is expected to begin in mid-2025

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