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Phase 1 investigator-initiated trial of eftilagimod alpha in conjunction with pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) in patients with various solid tuumours

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Trial Profile

Phase 1 investigator-initiated trial of eftilagimod alpha in conjunction with pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) in patients with various solid tuumours

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Aug 2024

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At a glance

  • Drugs Carboplatin (Primary) ; Eftilagimod alpha (Primary) ; Pembrolizumab (Primary) ; Pemetrexed (Primary)
  • Indications Adenocarcinoma; Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms INSIGHT-003
  • Most Recent Events

    • 31 Jul 2024 According to an Immutep Limited media release, this trial continued to enrol patients throughout the quarter, with 43 out of a target of 50 patients enrolled and safely dosed across six sites in Germany. Further updates from INSIGHT-003 will be provided in CY2024.
    • 29 Apr 2024 According to an Immutep Limited media release, 38 out of a total of 50 patients have been enrolled and safely dosed across six sites in Germany.
    • 22 Nov 2023 According to an Immutep Limited media release, the extension opened in mid-2023 and 29 patients have been enrolled to date. With the addition of the new sites, the trial is expected to complete recruitment in 1H CY2024.

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