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MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

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Trial Profile

MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Dec 2024

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At a glance

  • Drugs Nexiguran-ziclumeran (Primary)
  • Indications Transthyretin-related hereditary amyloidosis
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms MAGNITUDE
  • Sponsors Intellia Therapeutics

    • Most Recent Events

    • 07 Nov 2024 According to an Intellia Therapeutics media release, enrollment in this pivotal Phase 3 MAGNITUDE trial is progressing swiftly and continuing to track ahead of the Company's target enrollment projections.
    • 18 Mar 2024 According to an Intellia Therapeutics media release, Julian Gillmore, M.D., Ph.D., Professor of Medicine, National Amyloidosis Centre, UCL Division of Medicine, Royal Free Hospital, U.K., is the national coordinating investigator of the Phase 3 study.
    • 18 Mar 2024 According to an Intellia Therapeutics media release, first patient has been dosed in this trial. With multiple sites now enrolling patients, including in the U.S.

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