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A phase 1/2a, open-label trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of intrathecally administered VO659 in participants with spinocerebellar ataxia types 1, 3 and Huntington's disease

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Trial Profile

A phase 1/2a, open-label trial to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of intrathecally administered VO659 in participants with spinocerebellar ataxia types 1, 3 and Huntington's disease

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 04 Mar 2026

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At a glance

  • Drugs VO 659 (Primary)
  • Indications Huntington's disease; Spinocerebellar ataxias
  • Focus Adverse reactions; First in man
  • Sponsors Vico Therapeutics

Most Recent Events

  • 24 Feb 2026 According to a Vico Therapeutics media release, company announced that patient dosing has commenced in an expanded cohort of participants using a twice annual dosing regimen.
  • 13 Sep 2024 According to a Vico Therapeutics media release, company plans to meet with regulators later this year to discuss the optimal path forward for the VO659 program. The company plans to provide an update from the SCA1 and SCA3 patient cohorts at a future scientific meeting.
  • 13 Sep 2024 According to a Vico Therapeutics media release, Results will be highlighted in an oral presentation at the European Huntington's Disease Network's EHDN & Enroll-HD 2024 meeting on Friday, September 13, 2024 at 9:45 a.m. CET.

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