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A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication

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Trial Profile

A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 12 Jul 2024

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At a glance

  • Drugs Amlodipine (Primary) ; Olmesartan medoxomil (Primary) ; Zilebesiran (Primary) ; Indapamide
  • Indications Hypertension
  • Focus Therapeutic Use
  • Acronyms KARDIA-2
  • Sponsors Alnylam Pharmaceuticals
  • Most Recent Events

    • 28 Jun 2024 Planned End Date changed from 31 Dec 2025 to 20 Sep 2024.
    • 07 Apr 2024 According to an Alnylam Pharmaceuticals media release, the company management and Akshay Desai, M.D., Director of the Cardiomyopathy and Heart Failure Program, Brigham and Women's Hospital, will discuss the KARDIA-2 results via webcast on April 7, 2024, at 7:00 p.m. ET.
    • 07 Apr 2024 According to an Alnylam Pharmaceuticals media release, results form this trial were presented at the 2024 American College of Cardiology (ACC) Annual Scientific Session.
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