Trial Profile

Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 13 Oct 2025

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At a glance

Drugs Actinium 225 rosopatamab (Primary) ; Pembrolizumab (Primary) ; Apalutamide; Darolutamide; Enzalutamide
Indications Adenocarcinoma; Prostate cancer
Focus Adverse reactions; Therapeutic Use

Most Recent Events

25 Sep 2025 Planned End Date changed from 1 Jun 2028 to 1 Dec 2029.
25 Aug 2025 Planned primary completion date changed from 1 Jun 2026 to 1 Oct 2027.
16 Oct 2024 Status changed from suspended to recruiting.

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