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A randomized phase III trial of trastuzumab + ALpelisib +/- fulvestrant versus trastuzumab + chemotherapy in patients with PIK3CA mutated previously treated HER2+ Advanced BrEasT cancer

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A randomized phase III trial of trastuzumab + ALpelisib +/- fulvestrant versus trastuzumab + chemotherapy in patients with PIK3CA mutated previously treated HER2+ Advanced BrEasT cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 15 Apr 2024

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At a glance

  • Drugs Alpelisib (Primary) ; Fulvestrant (Primary) ; Trastuzumab (Primary) ; Trastuzumab (Primary) ; Capecitabine; Eribulin; Vinorelbine; Vinorelbine
  • Indications Advanced breast cancer; HER2 positive breast cancer; Male breast cancer
  • Focus Therapeutic Use
  • Acronyms ALPHABET

    • Most Recent Events

    • 09 Apr 2024 Planned End Date changed from 1 Sep 2026 to 1 Nov 2024.
    • 09 Apr 2024 Planned primary completion date changed from 1 Jun 2026 to 1 Nov 2024.
    • 09 Apr 2024 Status changed from recruiting to active, no longer recruiting.

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