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A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept Versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) Due to Heart Failure With Preserved Ejection Fraction (HFpEF)

Trial Profile

A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept Versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) Due to Heart Failure With Preserved Ejection Fraction (HFpEF)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 20 Apr 2026

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At a glance

  • Drugs Sotatercept (Primary)
  • Indications Heart failure; Pulmonary arterial hypertension
  • Focus Proof of concept; Therapeutic Use
  • Acronyms CADENCE
  • Sponsors Acceleron Pharma

Most Recent Events

  • 15 Apr 2026 Status changed from active, no longer recruiting to completed.
  • 29 Mar 2026 According to a Merck and Co media release, data from this trial were presented today in a late-breaking clinical trial presentation at the American College of Cardiologys Annual Scientific Session and Expo (ACC.26), simultaneously published in Circulation and featured as part of an ACC.26 press conference.
  • 29 Mar 2026 Results presented in the Merck and Co media release.

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